American Association for Cancer Research
crc-23-0009-s07.docx (172.46 kB)

Supplementary Fig 1 from Whole-genome CpG-resolution DNA Methylation Profiling of HNSCC Reveals Distinct Mechanisms of Carcinogenesis for Fine-scale HPV+ Cancer Subtypes

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journal contribution
posted on 2023-08-30, 14:20 authored by Tingting Qin, Shiting Li, Leanne E. Henry, Elysia Chou, Raymond G. Cavalcante, Bailey F. Garb, Nisha J. D'Silva, Laura S. Rozek, Maureen A. Sartor

Companion figure showing significance results for main Figure 1D-F and Figure 2A.


HHS | NIH | National Cancer Institute (NCI)



This study revealed that the previously observed hypermethylation of HPV(+) HNSCC is due solely to the IMU subtype, illustrating the importance of fine-scale subtype analysis in such a heterogeneous disease. Particularly, IMU has significantly higher methylation of transposable elements, which can be tested as a prognosis biomarker in future translational studies.