Supplementary Experimental Procedures from Neoantigen Presentation and IFNγ Signaling on the Same Tumor-associated Macrophage are Necessary for CD4 T Cell–mediated Antitumor Activity in Mice

Perez-Diez, Ainhoa; Liu, Xiangdong; Matzinger, Polly

doi:10.1158/2767-9764.22544700.v1

Supplementary Experimental Procedures from Neoantigen Presentation and IFNγ Signaling on the Same Tumor-associated Macrophage are Necessary for CD4 T Cell–mediated Antitumor Activity in Mice

https://doi.org/10.1158/2767-9764.22544700

journal contribution

posted on 2023-04-04, 01:25 authored by Ainhoa Perez-Diez, Xiangdong Liu, Polly Matzinger

<p>Supplementary Materials and Methods</p>

Funding

Division of Intramural Research, National Institute of Allergy and Infectious Diseases (DIR, NIAID)

History

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DOI - Is supplement to Neoantigen Presentation and IFNγ Signaling on the Same Tumor-associated Macrophage are Necessary for CD4 T Cell–mediated Antitumor Activity in Mice

ARTICLE ABSTRACT

In the tumor microenvironment, TAMs are capable of presenting tumor antigens to effector CD4 T cells. Upon antigen recognition, the CD4 cells transform transcriptionally, phenotypically, and functionally the TAMs inducing tumor rejection. This reeducation process requires both cognate interaction and IFNγ signaling on the same macrophage.