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Supplementary Data from Periostin+ Stromal Cells Guide Lymphovascular Invasion by Cancer Cells

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posted on 2023-07-05, 08:22 authored by Jamie L. Null, Dae Joong Kim, James V. McCann, Patcharin Pramoonjago, Jay W. Fox, Jianhao Zeng, Pankaj Kumar, Lincy Edatt, Chad V. Pecot, Andrew C. Dudley

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National Cancer Institute (NCI)

United States Department of Health and Human Services

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American Cancer Society (ACS)

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ARTICLE ABSTRACT

Highly metastatic breast cancer cells activate a population of periostin-expressing CAFs that remodel the extracellular matrix to promote escape of cancer cells into lymphatic vessels and drive colonization of proximal lymph nodes.

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