Supplementary Data from Nudix Hydrolase NUDT16 Regulates 53BP1 Protein by Reversing 53BP1 ADP-Ribosylation

Zhang, Fan; Lou, Lihong; Peng, Bo; Song, Xiaotian; Reizes, Ofer; Almasan, Alexandru; Gong, Zihua

doi:10.1158/0008-5472.22426345.v1

can-19-2205_supplementary-data.docx (23.19 kB)

Supplementary Data from Nudix Hydrolase NUDT16 Regulates 53BP1 Protein by Reversing 53BP1 ADP-Ribosylation

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posted on 2023-03-31, 03:46 authored by Fan Zhang, Lihong Lou, Bo Peng, Xiaotian Song, Ofer Reizes, Alexandru Almasan, Zihua Gong

Supplementary Data from Nudix Hydrolase NUDT16 Regulates 53BP1 Protein by Reversing 53BP1 ADP-Ribosylation

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ARTICLE ABSTRACT

This study provides a novel mechanism of 53BP1 regulation by demonstrating that NUDT16 has hydrolase activities that remove ADP-ribosylation of 53BP1 to regulate 53BP1 stability and 53BP1 localization at DSBs.

Supplementary Data from Nudix Hydrolase NUDT16 Regulates 53BP1 Protein by Reversing 53BP1 ADP-Ribosylation

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ARTICLE ABSTRACT

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