Supplementary Data from Molecular and Clinical Characterization of Postpartum-Associated Breast Cancer in the Carolina Breast Cancer Study Phase I–III, 1993–2013

Vohra, Sanah N.; Walens, Andrea; Hamilton, Alina M.; Sherman, Mark E.; Schedin, Pepper; Nichols, Hazel B.; Reeder-Hayes, Katherine E.; Olshan, Andrew F.; Love, Michael I.; Troester, Melissa A.

doi:10.1158/1055-9965.30721462

Supplementary Data from Molecular and Clinical Characterization of Postpartum-Associated Breast Cancer in the Carolina Breast Cancer Study Phase I–III, 1993–2013

https://doi.org/10.1158/1055-9965.30721462

journal contribution

posted on 2025-11-26, 13:00 authored by Sanah N. Vohra, Andrea Walens, Alina M. Hamilton, Mark E. Sherman, Pepper Schedin, Hazel B. Nichols, Katherine E. Reeder-Hayes, Andrew F. Olshan, Michael I. Love, Melissa A. Troester

Supplementary Data from Molecular and Clinical Characterization of Postpartum-Associated Breast Cancer in the Carolina Breast Cancer Study Phase I–III, 1993–2013

Funding

University Cancer Research Fund of North Carolina, the Komen Graduate Training in Disparities Research

UNC Cancer Control Education Program

NCI

NIH

University Cancer Research Fund of North Carolina and Susan G. Komen for the Cure

Komen Graduate Training in Disparities Research Grant

History

Related Materials

1.
DOI - Is supplement to Molecular and Clinical Characterization of Postpartum-Associated Breast Cancer in the Carolina Breast Cancer Study Phase I–III, 1993–2013

ARTICLE ABSTRACT

Breast cancers in recently postpartum women may have worse outcomes, but studies examining tumor molecular features by pregnancy recency have shown conflicting results. This analysis used Carolina Breast Cancer Study data to examine clinical and molecular tumor features among women less than 50 years of age who were recently (≤10 years prior) or remotely (>10 years prior) postpartum, or nulliparous. Prevalence odds ratios (POR) and 95% confidence intervals (CI) were estimated using multivariable models. Recently postpartum women (N = 618) were more frequently lymph node–positive [POR (95% CI): 1.66 (1.26–2.19)], estrogen receptor (ER)-negative [1.37 (1.02–1.83)], and IHC-based triple negative [1.57 (1.00–2.47)] compared with nulliparous (N = 360) women. Some differences were identified between recent versus remotely postpartum; smaller tumor size [0.67 (0.52–0.86)], p53 wildtype [0.53 (0.36–0.77)], and non–basal-like phenotype [0.53 (0.33–0.84)] were more common among recently postpartum. Recently postpartum (vs. nulliparous) had significant enrichment for adaptive immunity, T cells, B cells, CD8 T cells, activated CD8 T cells/natural killer (NK) cells, and T follicular helper (Tfh) cells and higher overall immune cell scores. These differences were attenuated in remotely (compared with recently) postpartum women. These results suggest a dominant effect of parity (vs. nulliparity) and a lesser effect of pregnancy recency on tumor molecular features, although tumor immune microenvironments were altered in association with pregnancy recency. Our study is unique in examining tumor immune microenvironment and RNA-based markers according to time since last childbirth. Future studies should examine the interplay between tumor features, postdiagnostic treatment, and outcomes among recently postpartum women.See related commentary by McDonald et al., p. 518