posted on 2023-03-31, 03:48authored byBinghe Tan, Xiujuan Shi, Jie Zhang, Juliang Qin, Na Zhang, Hua Ren, Min Qian, Stefan Siwko, Kendra Carmon, Qingyun Liu, Honghui Han, Bing Du, Mingyao Liu
This file contains the characterization of M2 (Supplementary Fig.S1) and M1 (Supplementary Fig.S2) type polarization in both Lgr4 knockdown and overexpression cells; the expression and immune regulation of Lgr4 in tumor tissues (Supplementary Fig.S3); the toxicity of LGR4 ECD, Rspo1 antibody and BLZ945 on tumor cells and macrophages (Supplementary Fig.S4); the immune regulation of Rspo/Lgr4 blockade in B16F10 melanoma mouse model (Supplementary Fig.S5).
Funding
National Key R&D Program of China
National Natural Science Foundation of China
Science and Technology Commission of Shanghai Municipality