Supplementary Data from Gemcitabine Synergizes with Immune Checkpoint Inhibitors and Overcomes Resistance in a Preclinical Model and Mesothelioma Patients

Tallón de Lara, Paulino; Cecconi, Virginia; Hiltbrunner, Stefanie; Yagita, Hideo; Friess, Martina; Bode, Beata; Opitz, Isabelle; Vrugt, Bart; Weder, Walter; Stolzmann, Paul; Felley-Bosco, Emanuela; Stahel, Rolf A.; Tischler, Verena; Britschgi, Christian; Soldini, Davide; van den Broek, Maries; Curioni-Fontecedro, Alessandra

doi:10.1158/1078-0432.22468337.v1

10780432ccr181231-sup-200514_2_supp_4955418_pd8493.docx (1.37 MB)

Supplementary Data from Gemcitabine Synergizes with Immune Checkpoint Inhibitors and Overcomes Resistance in a Preclinical Model and Mesothelioma Patients

journal contribution

posted on 2023-03-31, 20:26 authored by Paulino Tallón de Lara, Virginia Cecconi, Stefanie Hiltbrunner, Hideo Yagita, Martina Friess, Beata Bode, Isabelle Opitz, Bart Vrugt, Walter Weder, Paul Stolzmann, Emanuela Felley-Bosco, Rolf A. Stahel, Verena Tischler, Christian Britschgi, Davide Soldini, Maries van den Broek, Alessandra Curioni-Fontecedro

Supplementary data

History

ARTICLE ABSTRACT

Combination of immune checkpoint inhibitors with chemotherapy is under investigation for cancer treatment. We studied the rationale of such a combination for treating mesothelioma, a disease with limited treatment options. The combination of gemcitabine and immune checkpoint inhibitors outperformed immunotherapy alone with regard to tumor control and survival in a preclinical mesothelioma model; however, the addition of dexamethasone to gemcitabine and immune checkpoint inhibitors nullified the synergistic clinical response. Furthermore, treatment with gemcitabine plus anti-PD-1 resulted in an objective clinical response in two patients with mesothelioma, who were resistant to gemcitabine or anti-PD-1 as monotherapy. Thus, treatment of mesothelioma with a combination of gemcitabine with immune checkpoint inhibitors is feasible and results in synergistic clinical response compared with single treatment in the absence of steroids.