American Association for Cancer Research
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Supplementary Data from Classifying cGAS-STING Activity Links Chromosomal Instability with Immunotherapy Response in Metastatic Bladder Cancer

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posted on 2023-04-04, 01:43 authored by Mateo Sokač, Johanne Ahrenfeldt, Kevin Litchfield, Thomas B.K. Watkins, Michael Knudsen, Lars Dyrskjøt, Martin R. Jakobsen, Nicolai J. Birkbak

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Funding

Lundbeckfonden (Lundbeck Foundation)

Aarhus Universitets Forskningsfond (Aarhus University Research Foundation)

Danish Cancer Society Research Center (DCRC)

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ARTICLE ABSTRACT

The cGAS-STING pathway is induced by CIN, triggers inflammation and is often deficient in cancer. We provide a tool to evaluate cGAS-STING activity and demonstrate clinical significance in immunotherapy response.

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    Cancer Research Communications

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    Keywords

    BiomarkersPrognostic biomarkersGenitourinary CancersBladder cancerImmunologyImmune responses to cancerComputational MethodsGene expression profilingImmunotherapyDna Damage And RepairGenomic instability

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    CC BY

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