Supplementary Data from Analysis of the Estrogen Receptor-Associated LncRNA Landscape Identifies a Role for ERLC1 in Breast Cancer Progression

Supplementary table S1 lists 22 breast cancer and ERα associated lncRNAs. Supplementary table S2 lists all primers sequences, oligonucleotides sequences, and probes sequences used in this study. Supplementary table S3 shows the information of antibodies used in this study. Supplementary table S4 shows the sequence of ERLC1 in the overexpression system. Supplementary figure S1 shows that ERLC1 is screened as an ERα-regulated gene in breast cancer. Supplementary figure S2 shows that ERLC1 is an oncogene in MCF-7 and T47D cells. Supplementary figure S3 shows that ERLC1 regulates anti-estrogen sensitivity and tamoxifen resistance in T47D cells. Supplementary figure S4 shows that miR-129 is a tumor suppressor gene and ERLC1 expression is negatively correlated with miR-129 levels. Supplementary figure S5 shows that ERLC1 promotes ESR1 expression through sequestration of miR-129. Supplementary figure S6 shows that ERLC1 and FXR1 form a functional complex stabilizing ESR1 mRNA. Supplementary figure S7 shows that ESR1 mutants did not interact with ERLC1 promoter. Supplementary figure S8 shows that ERLC1 depletion reduces resistance to fulvestrant and palbociclib in MCF-7 TamR cells.