Supplementary Data Figure 3 from Metastatic Competency and Tumor Spheroid Formation Are Independent Cell States Governed by RB in Lung Adenocarcinoma

Freeburg, Nelson F.; Peterson, Nia; Ruiz, Dain A.; Gladstein, Amy C.; Feldser, David M.

doi:10.1158/2767-9764.24234018.v1

Supplementary Data Figure 3 from Metastatic Competency and Tumor Spheroid Formation Are Independent Cell States Governed by RB in Lung Adenocarcinoma

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posted on 2023-10-03, 02:20 authored by Nelson F. Freeburg, Nia Peterson, Dain A. Ruiz, Amy C. Gladstein, David M. Feldser

Hallmark gene sets enriched in Group 1 vs. Group 2.

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DOD | USA | MEDCOM | U.S. Army Medical Research and Development Command (MRDC)

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ARTICLE ABSTRACT

Members of the RB pathway are frequently mutated in lung adenocarcinoma. We show that RB regulates cell state plasticity, tumor spheroid formation, and metastatic competency. Our data indicate that these are independent states where spheroid formation is distinct from metastatic competency. Thus, we caution against conflating spheroid formation and other signs of cell state plasticity with advanced metastatic cell states. Nevertheless, our work supports clinical strategies to reactivate RB pathways.

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Lung Cancer Oncogenes & Tumor Suppressors RB and family Preclinical Models Organoids Progression, Invasion & Metastasis Metastasis Tumor progression

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Supplementary Data Figure 3 from Metastatic Competency and Tumor Spheroid Formation Are Independent Cell States Governed by RB in Lung Adenocarcinoma

Funding

DOD | USA | MEDCOM | U.S. Army Medical Research and Development Command (MRDC)

History

ARTICLE ABSTRACT

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