American Association for Cancer Research
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Supplemental figures 7-8 from Tenascin-C and Integrin α9 Mediate Interactions of Prostate Cancer with the Bone Microenvironment

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posted on 2023-03-31, 01:44 authored by Rebeca San Martin, Ravi Pathak, Antrix Jain, Sung Yun Jung, Susan G. Hilsenbeck, María C. Piña-Barba, Andrew G. Sikora, Kenneth J. Pienta, David R. Rowley

Characterization of the tenascin-c coated trabecular bone scaffold system.

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ARTICLE ABSTRACT

Deposition of the extracellular matrix protein tenascin-C is part of the reactive stroma response, which has a critical role in prostate cancer progression. Here, we report that tenascin C is expressed in the bone endosteum and is associated with formation of prostate bone metastases. Metastatic cells cultured on osteo-mimetic surfaces coated with tenascin C exhibited enhanced adhesion and colony formation as mediated by integrin α9β1. In addition, metastatic cells preferentially migrated and colonized tenascin-C–coated trabecular bone xenografts in a novel system that employed chorioallantoic membranes of fertilized chicken eggs as host. Overall, our studies deepen knowledge about reactive stroma responses in the bone endosteum that accompany prostate cancer metastasis to trabecular bone, with potential implications to therapeutically target this process in patients. Cancer Res; 77(21); 5977–88. ©2017 AACR.

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    Cancer Research

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    CarcinogenesisTumor initiation and promotionCell SignalingCell adhesionGenitourinary CancersProstate cancerProgression, Invasion & MetastasisCell adhesion and extracellular matrixTumor progressionTumor MicroenvironmentTumor-stromal cell interactions

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