Supplemental Table S2 from BRCA1-Associated RING Domain-1 (BARD1) Loss and GBP1 Expression Enhance Sensitivity to DNA Damage in Ewing Sarcoma

Maurer, Lisa M.; Daley, Jessica D.; Mukherjee, Elina; Venier, Rosemarie E.; Julian, Claire M.; Bailey, Nathanael G.; Jacobs, Michelle F.; Kumar-Sinha, Chandan; Raphael, Haley; Periyapatna, Nivitha; Weiss, Kurt; Janeway, Katherine A.; Mody, Rajen; Lucas, Peter C.; McAllister-Lucas, Linda M.; Bailey, Kelly M.

doi:10.1158/2767-9764.22544706.v1

Supplemental Table S2 from BRCA1-Associated RING Domain-1 (BARD1) Loss and GBP1 Expression Enhance Sensitivity to DNA Damage in Ewing Sarcoma

journal contribution

posted on 2023-04-04, 01:25 authored by Lisa M. Maurer, Jessica D. Daley, Elina Mukherjee, Rosemarie E. Venier, Claire M. Julian, Nathanael G. Bailey, Michelle F. Jacobs, Chandan Kumar-Sinha, Haley Raphael, Nivitha Periyapatna, Kurt Weiss, Katherine A. Janeway, Rajen Mody, Peter C. Lucas, Linda M. McAllister-Lucas, Kelly M. Bailey

Prevalence of somatic DNA damage repair gene variants in Ewing cell lines included in original studies of PARP inhibition.

Funding

Alex's Lemonade Stand Foundation for Childhood Cancer (ALSF)

현대자동차그룹 | Hyundai Motor America | Hyundai Hope On Wheels (Hope On Wheels)

HHS | NIH | National Cancer Institute (NCI)

HHS | National Institutes of Health (NIH)

Burroughs Wellcome Fund (BWF)

History

ARTICLE ABSTRACT

This work provides preclinical support for the inclusion of pediatric patients with advanced Ewing sarcoma and pathogenic germline variants in BARD1 in future clinical trials testing novel agents inducing DNA damage/targeting DNA damage repair.