<p>Supplemental Table S1: Model results additionally adjusted for BMI and SMI, and time-varying model results</p>
ARTICLE ABSTRACT
Determine if dual-energy X-ray absorptiometry (DXA)–derived adiposity was associated with colorectal cancer incidence and mortality in postmenopausal women from the Women’s Health Initiative DXA cohort.
Whole-body DXA scans estimated adiposity. Women with a history of cancer (except nonmelanoma skin cancer) or missing baseline DXA were excluded. For 27 years of follow-up, outcomes and deaths were adjudicated. Descriptive statistics by colorectal cancer status were calculated. Fine and Gray’s competing risks regression was used to estimate sub-HRs and 95% confidence intervals. Observation time was from enrollment to the first colorectal cancer event or competing risk (other cancer, other cause of death); women without cancer at the last follow-up were censored. Covariates included sociodemographic, clinical, and study characteristics.
After exclusions, 9,950 women were included, with 191 first-incident colorectal cancer cases and 88 colorectal cancer–related deaths identified. At baseline, the mean (±SD) age was 63.3 (±7.4) years, and the body mass index (BMI) was 28.2 (±5.7) kg/m2. In adjusted models, baseline continuous abdominal visceral adipose tissue (VAT; per 100 cm2) and android fat (per kg) were significantly associated with a higher risk of first-incident colorectal cancer: sub-HRs (95% confidence interval) were 1.23 (1.04–1.45) and 1.15 (1.01–1.31), respectively. There were no significant associations between adiposity and colorectal cancer mortality.
Higher amounts of abdominal VAT and android fat were associated with a higher risk of colorectal cancer incidence in postmenopausal women.
Associations between VAT and colorectal cancer, independent of BMI, support the clinical assessment of body composition across weight categories. A head-to-head comparison of VAT and BMI for colorectal cancer prediction is recommended in future research.
