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Supplemental Table 7 from Lifetime Exposure to Cigarette Smoke, B-Cell Tumor Immune Infiltration, and Immunoglobulin Abundance in Ovarian Tumors

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posted on 2024-06-03, 07:42 authored by Cassandra A. Hathaway, Mary K. Townsend, Tianyi Wang, Christine Vinci, Danielle E. Jake-Schoffman, Jonathan L. Hecht, Daryoush Saeed-Vafa, Carlos Moran Segura, Jonathan V. Nguyen, Jose R. Conejo-Garcia, Brooke L. Fridley, Shelley S. Tworoger

Supplemental Table 7: Hazard ratios and 95% confidence intervals between smoking and ovarian cancer risk by tumor immune infiltration of B cells, NHS and NHSII

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National Cancer Institute (NCI)

United States Department of Health and Human Services

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Florida Department of Health (DOH)

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ARTICLE ABSTRACT

Cigarette smoke exposure has been linked to systemic immune dysfunction, including for B-cell and immunoglobulin (Ig) production, and poor outcomes in patients with ovarian cancer. No study has evaluated the impact of smoke exposure across the life-course on B-cell infiltration and Ig abundance in ovarian tumors. We measured markers of B and plasma cells and Ig isotypes using multiplex immunofluorescence on 395 ovarian cancer tumors in the Nurses’ Health Study (NHS)/NHSII. We conducted beta-binomial analyses evaluating odds ratios (OR) and 95% confidence intervals (CI) for positivity of immune markers by cigarette exposure among cases and Cox proportional hazards models to evaluate hazard ratios (HR) and 95% CI for developing tumors with low (

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    Cancer Epidemiology, Biomarkers & Prevention

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    Keywords

    EpidemiologyGynecological CancersOvarian cancerImmunology

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