posted on 2023-04-04, 02:20authored byTing-Yuan David Cheng, Runzhi Zhang, Zhihong Gong, Bo Qin, Rikki A. Cannioto, Susmita Datta, Weizhou Zhang, Angela R. Omilian, Song Yao, Thaer Khoury, Chi-Chen Hong, Elisa V. Bandera, Christine B. Ambrosone
Supplemental Table 5 reports the association without adjusting BMI as a sensitivity analysis.
Funding
HHS | NIH | National Cancer Institute (NCI)
Breast Cancer Research Foundation (BCRF)
DOD | USA | U.S. Army Materiel Command (AMC)
History
ARTICLE ABSTRACT
PA increases energy expenditure and limits energy utilization in the cell, which can influence the mTOR pathway that is central to sensing energy influx and regulating cell growth. We studied exercise-mediated mTOR pathway activities in breast tumor and adjacent-normal tissue. Despite the discrepancies between animal and human data and the limitations of our approach, the findings provide a foundation to study the mechanisms of PA and their clinical implications.