American Association for Cancer Research
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Supplemental Table 4 from Association Between Recreational Physical Activity and mTOR Signaling Pathway Protein Expression in Breast Tumor Tissue

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posted on 2023-04-04, 02:20 authored by Ting-Yuan David Cheng, Runzhi Zhang, Zhihong Gong, Bo Qin, Rikki A. Cannioto, Susmita Datta, Weizhou Zhang, Angela R. Omilian, Song Yao, Thaer Khoury, Chi-Chen Hong, Elisa V. Bandera, Christine B. Ambrosone

Supplemental Table 4 shows the associations adjusting covariates and total energy intake.

Funding

HHS | NIH | National Cancer Institute (NCI)

Breast Cancer Research Foundation (BCRF)

DOD | USA | U.S. Army Materiel Command (AMC)

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ARTICLE ABSTRACT

PA increases energy expenditure and limits energy utilization in the cell, which can influence the mTOR pathway that is central to sensing energy influx and regulating cell growth. We studied exercise-mediated mTOR pathway activities in breast tumor and adjacent-normal tissue. Despite the discrepancies between animal and human data and the limitations of our approach, the findings provide a foundation to study the mechanisms of PA and their clinical implications.

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    Cancer Research Communications

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    Keywords

    Tumor MicroenvironmentCell SignalingGrowth factorsBreast CancerTranslational ResearchEpidemiology

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