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Supplemental Figure S3 from BRCA1-Associated RING Domain-1 (BARD1) Loss and GBP1 Expression Enhance Sensitivity to DNA Damage in Ewing Sarcoma

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posted on 2023-04-04, 01:25 authored by Lisa M. Maurer, Jessica D. Daley, Elina Mukherjee, Rosemarie E. Venier, Claire M. Julian, Nathanael G. Bailey, Michelle F. Jacobs, Chandan Kumar-Sinha, Haley Raphael, Nivitha Periyapatna, Kurt Weiss, Katherine A. Janeway, Rajen Mody, Peter C. Lucas, Linda M. McAllister-Lucas, Kelly M. Bailey

Interferon-gamma-induced GBP1 expression in A673 Ewing sarcoma cells.

Funding

Alex's Lemonade Stand Foundation for Childhood Cancer (ALSF)

현대자동차그룹 | Hyundai Motor America | Hyundai Hope On Wheels (Hope On Wheels)

HHS | NIH | National Cancer Institute (NCI)

HHS | National Institutes of Health (NIH)

Burroughs Wellcome Fund (BWF)

History

ARTICLE ABSTRACT

This work provides preclinical support for the inclusion of pediatric patients with advanced Ewing sarcoma and pathogenic germline variants in BARD1 in future clinical trials testing novel agents inducing DNA damage/targeting DNA damage repair.

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    Cancer Research Communications

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    Keywords

    Pediatric CancersRare CancersSarcomasDna Damage And RepairDNA repairTumor HeterogeneityRadiobiologyModulators of radiation response

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    CC BY

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