American Association for Cancer Research
15417786mcr190125-sup-216606_2_supp_5641555_pshjfz.docx (12.11 kB)

Supplemental Figure Legends from Deciphering the Role of Protein Kinase D1 (PKD1) in Cellular Proliferation

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journal contribution
posted on 2023-04-03, 16:46 authored by Ilige Youssef, Jean-Marc Ricort

Supplemental Figure Legends 1-8



Protein kinase D1 (PKD1) is a serine/threonine kinase that belongs to the calcium/calmodulin-dependent kinase family, and is involved in multiple mechanisms implicated in tumor progression such as cell motility, invasion, proliferation, protein transport, and apoptosis. While it is expressed in most tissues in the normal state, PKD1 expression may increase or decrease during tumorigenesis, and its role in proliferation is context-dependent and poorly understood. In this review, we present and discuss the current landscape of studies investigating the role of PKD1 in the proliferation of both cancerous and normal cells. Indeed, as a potential therapeutic target, deciphering whether PKD1 exerts a pro- or antiproliferative effect, and under what conditions, is of paramount importance.

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    Molecular Cancer Research