American Association for Cancer Research
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Supplemental Figure 4 from Siglec-15 Promotes Evasion of Adaptive Immunity in B-cell Acute Lymphoblastic Leukemia

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posted on 2023-07-17, 14:20 authored by Claire E. Pillsbury, Jodi Dougan, Jennifer L. Rabe, Jairo A. Fonseca, Chengjing Zhou, Alyssa N. Evans, Hasan Abukharma, Ona Ichoku, Gloria Gonzalez-Flamenco, Sunita I. Park, Ahmed Aljudi, Deborah DeRyckere, Sharon M. Castellino, Sarwish Rafiq, Solomon Langermann, Linda N. Liu, Curtis J. Henry, Christopher C. Porter

Sig15 is required for immune evasion by murine B-ALL.

Funding

Leukemia and Lymphoma Society (LLS)

CURE Childhood Cancer (CURE)

Alex's Lemonade Stand Foundation for Childhood Cancer (ALSF)

현대자동차그룹 | Hyundai Motor America | Hyundai Hope On Wheels (Hope On Wheels)

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ARTICLE ABSTRACT

We demonstrate that Sig15 is overexpressed in hematologic malignancies driven by NFκB, is required for immune evasion in a mouse model of leukemia, and, for the first time, that it circulates at high levels in the plasma of children with leukemia.

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    Cancer Research Communications

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    Keywords

    Hematological CancersLeukemiasLymphomasPediatric CancersTumor MicroenvironmentImmunologyTumor immunology animal modelsTumor resistance to immune responseBiomarkersTranslational Research

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    CC BY

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