Supplemental Figure 1 from Kinetics of Nirogacestat-Mediated Increases in B-cell Maturation Antigen on Plasma Cells Inform Therapeutic Combinations in Multiple Myeloma

Shearer, Todd; Comstock, Melissa; Williams, Rex L.; Johnson, Mark C.; Cendrowicz, Ewa; Leonowens, Cathrine; Smith, Margaret; Baughman, Todd M.; Breitbach, Caroline J.; Cheng, Shinta; Green, Damian J.

doi:10.1158/2767-9764.28006932

Supplemental Figure 1 from Kinetics of Nirogacestat-Mediated Increases in B-cell Maturation Antigen on Plasma Cells Inform Therapeutic Combinations in Multiple Myeloma

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posted on 2024-12-11, 10:20 authored by Todd Shearer, Melissa Comstock, Rex L. Williams, Mark C. Johnson, Ewa Cendrowicz, Cathrine Leonowens, Margaret Smith, Todd M. Baughman, Caroline J. Breitbach, Shinta Cheng, Damian J. Green

Isolation of BCMA-expressing PCs in whole blood and bone marrow

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GSIs can enhance multiple myeloma therapies targeting BCMA by increasing mbBCMA on plasma cells. In response to the GSI nirogacestat, mbBCMA rapidly and robustly increased in vitro and in vivo. Elucidating nirogacestat’s effects on BCMA kinetics will guide potential multiple myeloma dosing strategies.

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Cell Surface Receptor Drug Targets Clinical Trial Results Clinical-stage Research Drug Targets Hematological Cancers In Vitro Models Of Cancer Myelomas Phase I Clinical Trials Preclinical Models Small Molecule Agents

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Supplemental Figure 1 from Kinetics of Nirogacestat-Mediated Increases in B-cell Maturation Antigen on Plasma Cells Inform Therapeutic Combinations in Multiple Myeloma

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ARTICLE ABSTRACT

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