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Suppl Figure S12 from Inhibition of Microsomal Prostaglandin E2 Synthase Reduces Collagen Deposition in Melanoma Tumors and May Improve Immunotherapy Efficacy by Reducing T-cell Exhaustion

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posted on 2023-07-31, 14:20 authored by Yasunari Fukuda, Sun-Hee Kim, Matias A. Bustos, Sung-Nam Cho, Jason Roszik, Jared K. Burks, Hong Kim, Dave S.B. Hoon, Elizabeth A. Grimm, Suhendan Ekmekcioglu

Figure S12 shows the Frequencies of tumor-infiltrating immune cells in tumors treated with celecoxib or CAY10678 as monotherapy or combined with and PD-1 blockade

Funding

HHS | NIH | National Cancer Institute (NCI)

Foundation for the National Institutes of Health (FNIH)

Dr. Miriam and Sheldon G. Adelson Medical Research Foundation (AMRF)

AIM at Melanoma (AIM at Melanoma Foundation)

Jim Malvo Foundation

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ARTICLE ABSTRACT

Collagen is a predominant component of the extracellular matrix that may influence the tumor immune microenvironment for cancer progression. We present here that mPGES-1 has specific roles in regulating tumor immunity, associated with several collagen-related genes and propose that pharmacologic inhibition of mPGES-1 may hold therapeutic promise for improving immune checkpoint–based therapies.

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    Cancer Research Communications

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    Keywords

    ImmunotherapySkin CancersMelanomaImmunologyT cell exhaustion

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