American Association for Cancer Research
Browse
crc-23-0210-s13.pdf (380.99 kB)

Suppl Figure S11 from Inhibition of Microsomal Prostaglandin E2 Synthase Reduces Collagen Deposition in Melanoma Tumors and May Improve Immunotherapy Efficacy by Reducing T-cell Exhaustion

Download (380.99 kB)
journal contribution
posted on 2023-07-31, 14:20 authored by Yasunari Fukuda, Sun-Hee Kim, Matias A. Bustos, Sung-Nam Cho, Jason Roszik, Jared K. Burks, Hong Kim, Dave S.B. Hoon, Elizabeth A. Grimm, Suhendan Ekmekcioglu

Figure S11 shows the effect of CAY10678 on the production of arachidonic acid metabolites from murine BrafV600E melanoma cells

Funding

HHS | NIH | National Cancer Institute (NCI)

Foundation for the National Institutes of Health (FNIH)

Dr. Miriam and Sheldon G. Adelson Medical Research Foundation (AMRF)

AIM at Melanoma (AIM at Melanoma Foundation)

Jim Malvo Foundation

History

ARTICLE ABSTRACT

Collagen is a predominant component of the extracellular matrix that may influence the tumor immune microenvironment for cancer progression. We present here that mPGES-1 has specific roles in regulating tumor immunity, associated with several collagen-related genes and propose that pharmacologic inhibition of mPGES-1 may hold therapeutic promise for improving immune checkpoint–based therapies.

Usage metrics

    Cancer Research Communications

    Licence

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC