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Figures S1-S6, Tables S8-S10 from A Phenogenetic Axis that Modulates Clinical Manifestation and Predicts Treatment Outcome in Primary Myeloid Neoplasms

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posted on 2023-04-04, 01:25 authored by Qiujin Shen, Yahui Feng, Xiaowen Gong, Yujiao Jia, Qingyan Gao, Xiaokang Jiao, Saibing Qi, Xueou Liu, Hui Wei, Bingqing Huang, Ningning Zhao, Xiaoqiang Song, Yueshen Ma, Shihao Liang, Donglei Zhang, Li Qin, Ying Wang, Shiqiang Qu, Yao Zou, Yumei Chen, Ye Guo, Shuhua Yi, Gang An, Zengtao Jiao, Song Zhang, Linfeng Li, Jun Yan, Huijun Wang, Zhen Song, Yingchang Mi, Lugui Qiu, Xiaofan Zhu, Jianxiang Wang, Zhijian Xiao, Junren Chen

Figure S1. The most prevalent gene mutations and chromosomal abnormalities for AML in THAMP. Figure S2. The most prevalent gene mutations and chromosomal abnormalities for MDS in THAMP. Figure S3. The most prevalent gene mutations and chromosomal abnormalities for MDS/MPN in THAMP. Figure S4. The most prevalent gene mutations and chromosomal abnormalities for MPN in THAMP. Figure S5. Ranking order of genes along the Pan-Myeloid Axis. Figure S6. Ranking order of clinical features along the Pan-Myeloid Axis. Table S8. Clinical features in THAMP. Table S9. ELN risk stratification of AML patients in THAMP. Table S10. Classification and risk stratification of MDS patients in THAMP.

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Tianjin Science and Technology Plan

Chinese Academy of Medical Sciences (CAMS)

State Key Laboratory of Experimental Hematology (SKLEH)

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ARTICLE ABSTRACT

The current criteria for disease diagnosis treat myeloid neoplasms as a group of distinct, separate diseases. This work provides genomics evidence for a “myeloid neoplasm continuum” and suggests that boundaries between myeloid neoplastic diseases are much more blurred than previously thought.

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