Figure SF3 from Plexin-B1 Mutation Drives Metastasis in Prostate Cancer Mouse Models

Shorning, Boris; Trent, Neil; Griffiths, David F.; Worzfeld, Thomas; Offermanns, Stefan; Smalley, Matthew J.; Williamson, Magali

doi:10.1158/2767-9764.22546927.v1

crc-22-0480-s03.pdf (463.69 kB)

Figure SF3 from Plexin-B1 Mutation Drives Metastasis in Prostate Cancer Mouse Models

journal contribution

posted on 2023-04-04, 02:22 authored by Boris Shorning, Neil Trent, David F. Griffiths, Thomas Worzfeld, Stefan Offermanns, Matthew J. Smalley, Magali Williamson

Metastases in Ptenfl/flKrasG12V mice

Funding

prostate cancer research (charity no. 1156027)

History

ARTICLE ABSTRACT

Few therapeutic targets have been identified specifically for preventing locally invasive/oligometastatic prostate cancer from becoming more widely disseminated. Our findings suggest Plexin-B1 signaling, particularly from the clinically relevant P1597L mutant, is such a target.

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Keywords

Oncogenes & Tumor Suppressors Suppressors of metastasis Progression, Invasion & Metastasis Metastasis Genitourinary Cancers Prostate cancer Preclinical Models Animal models of cancer

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CC BY

Figure SF3 from Plexin-B1 Mutation Drives Metastasis in Prostate Cancer Mouse Models

Funding

prostate cancer research (charity no. 1156027)

History

ARTICLE ABSTRACT

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Keywords

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