American Association for Cancer Research
crc-23-0139-s06.docx (109.29 kB)

Figure S6 from Systemic Treatments and Molecular Biomarkers for Perivascular Epithelioid Cell Tumors: A Single-institution Retrospective Analysis

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journal contribution
posted on 2023-07-12, 02:20 authored by Stefano Testa, Nam Q. Bui, Kristen N. Ganjoo

Figure S6 shows Kaplan-Meier curves for clinical PFS from first-line therapy in patients with PEComas, and specifically effect of TFE3 positivity, TSC1/TSC2 mutational status, and uterine versus extra-uterine location on clinical PFS.





This study examines systemic treatments for advanced PEComas, a rare group of sarcomas, and identifies molecular biomarkers of prognosis. Our results show that mTOR inhibitors have similar efficacy as chemotherapy, and that TFE3 overexpression, on IHC or FISH, correlates with a more aggressive disease course.