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Figure S6 from Mitochondria Transfer from Mesenchymal Stem Cells Confers Chemoresistance to Glioblastoma Stem Cells through Metabolic Rewiring

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posted on 2023-06-14, 14:20 authored by Jean Nakhle, Khattar Khattar, Tülin Özkan, Adel Boughlita, Daouda Abba Moussa, Amélie Darlix, Frédérique Lorcy, Valérie Rigau, Luc Bauchet, Sabine Gerbal-Chaloin, Martine Daujat-Chavanieu, Floriant Bellvert, Laurent Turchi, Thierry Virolle, Jean-Philippe Hugnot, Nicolas Buisine, Mireille Galloni, Valérie Dardalhon, Anne-Marie Rodriguez, Marie-Luce Vignais

Metabolite detection in resected GBM from 8 patients, at 1rst resection and at 2nd resection post-TMZ treatment. For each metabolite, the C12/C13 ratios normalized to tissue protein concentrations are indicated.

Funding

Ligue Contre le Cancer (French League Against Cancer)

Fondation ARC pour la Recherche sur le Cancer (ARC)

Institut National Du Cancer (INCa)

Région Occitanie Pyrénées-Méditerranée

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ARTICLE ABSTRACT

Mitochondria acquired from MSCs enhance the chemoresistance of GBMs. The discovery that they also generate metabolic vulnerability in GSCs paves the way for novel therapeutic approaches.

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    Cancer Research Communications

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    Keywords

    CNS CancersGliomas, GlioblastomasMetabolismMetabolomicsMitochondrial functionTumor MicroenvironmentTumor-stromal cell interactionsSmall Molecule AgentsAlkylating agentsDrug Resistance

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    CC BY

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