Figure S5 from PINK1-Mediated Mitochondrial Activity Confers Olaparib Resistance in Prostate Cancer Cells

Schaaf, Zachary A.; Ning, Shu; Leslie, Amy R.; Sharifi, Masuda; Gao, Richard Y.; Maine, James P.; Lou, Wei; Lombard, Alan P.; Liu, Chengfei; Yu, Ai-Ming; Mitsiades, Nicholas; Gao, Allen C.

doi:10.1158/2767-9764.27864198

Figure S5 from PINK1-Mediated Mitochondrial Activity Confers Olaparib Resistance in Prostate Cancer Cells

journal contribution

posted on 2024-11-20, 11:40 authored by Zachary A. Schaaf, Shu Ning, Amy R. Leslie, Masuda Sharifi, Richard Y. Gao, James P. Maine, Wei Lou, Alan P. Lombard, Chengfei Liu, Ai-Ming Yu, Nicholas Mitsiades, Allen C. Gao

Supplementary data

History

ARTICLE ABSTRACT

Olaparib, a PARP inhibitor, is effective against various cancers, including prostate cancer. However, resistance to olaparib poses a significant challenge. This study uncovers that mitochondrial alterations and PINK1 gene overexpression contribute to this resistance in prostate cancer cells. Enhanced mitochondrial functionality and increased PINK1 expression in olaparib-resistant cells underscore the importance of targeting mitochondrial dynamics and PINK1 to develop more effective treatments for overcoming olaparib resistance in prostate cancer.