American Association for Cancer Research
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Figure S5 from Loss of Dok-3 in Non-tumor Cells Induces Malignant Transformation of Benign Epithelial Tumor Cells of the Intestine

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journal contribution
posted on 2023-04-04, 02:02 authored by Sumimasa Arimura, Akane Inoue-Yamauchi, Kotoe Katayama, Tatsuo Kanno, Hiroki Jozawa, Seiya Imoto, Yuji Yamanashi

Characterization of invasive tumors in Apc/Dok3 mice.


MEXT | Japan Society for the Promotion of Science (JSPS)

OU | Research Institute for Microbial Diseases, Osaka University (RIMD)



This study uncovers tumor cell–extrinsic cues that can induce malignant conversion of benign tumors without intensifying mutagenesis in tumors, a novel concept potentially providing a new therapeutic target in malignancy.