Figure S5 from Loss of Dok-3 in Non-tumor Cells Induces Malignant Transformation of Benign Epithelial Tumor Cells of the Intestine

Arimura, Sumimasa; Inoue-Yamauchi, Akane; Katayama, Kotoe; Kanno, Tatsuo; Jozawa, Hiroki; Imoto, Seiya; Yamanashi, Yuji

doi:10.1158/2767-9764.22546197.v1

crc-22-0347-s07.pdf (319.9 kB)

Figure S5 from Loss of Dok-3 in Non-tumor Cells Induces Malignant Transformation of Benign Epithelial Tumor Cells of the Intestine

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posted on 2023-04-04, 02:02 authored by Sumimasa Arimura, Akane Inoue-Yamauchi, Kotoe Katayama, Tatsuo Kanno, Hiroki Jozawa, Seiya Imoto, Yuji Yamanashi

Characterization of invasive tumors in Apc/Dok3 mice.

Funding

MEXT | Japan Society for the Promotion of Science (JSPS)

OU | Research Institute for Microbial Diseases, Osaka University (RIMD)

History

ARTICLE ABSTRACT

This study uncovers tumor cell–extrinsic cues that can induce malignant conversion of benign tumors without intensifying mutagenesis in tumors, a novel concept potentially providing a new therapeutic target in malignancy.

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Keywords

Gastrointestinal Cancers Colorectal cancer Carcinogenesis Tumor initiation and promotion Tumor Microenvironment Tumor-stromal cell interactions

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Figure S5 from Loss of Dok-3 in Non-tumor Cells Induces Malignant Transformation of Benign Epithelial Tumor Cells of the Intestine

Funding

MEXT | Japan Society for the Promotion of Science (JSPS)

OU | Research Institute for Microbial Diseases, Osaka University (RIMD)

History

ARTICLE ABSTRACT

Usage metrics

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Keywords

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