American Association for Cancer Research
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Figure S5 from Detection of MET Polysomy by Next-generation Sequencing and Its Clinical Relevance for MET Inhibitors

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posted on 2023-04-04, 14:23 authored by Boyang Sun, Tian Qiu, Xiaoling Zeng, Jianchun Duan, Hua Bai, Jiachen Xu, Jin Li, Junling Li, Xuezhi Hao, Yutao Liu, Lin Lin, Hongyu Wang, Xin Zhang, Jia Zhong, Jie Wang, Jianming Ying, Zhijie Wang

One MET-FISH-negative patient was classified as having MET polysomy by NGS

Funding

MOST | National Key Research and Development Program of China (NKPs)

National Natural Science Foundation of China (NSFC)

Natural Science Foundation of Beijing Municipality (Beijing Natural Science Foundation)

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ARTICLE ABSTRACT

In this study, we established a methodology to differentiate polysomy from normal copy numbers and amplification using NGS. Moreover, this study suggests that it is critical to discriminate MET polysomy from amplification, for the former may dilute the clinical benefit of MET inhibitors.

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    Cancer Research Communications

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    Keywords

    Lung CancerLiquid BiopsyPrecision MedicineDrug Targets

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