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Figure S5 from Combination of a New Oral Demethylating Agent, OR2100, and Venetoclax for Treatment of Acute Myeloid Leukemia

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posted on 2023-04-04, 02:05 authored by Kazuharu Kamachi, Hiroshi Ureshino, Tatsuro Watanabe, Nao Yoshida-Sakai, Yuki Fukuda-Kurahashi, Kazunori Kawasoe, Toshimi Hoshiko, Yuta Yamamoto, Yuki Kurahashi, Shinya Kimura

Figure S5. The combination effect of venetoclax (Ven) and S63845 (S6) in acute myeloid leukemia.

Funding

Shinnihon Foundation of Advanced Medical Treatment Research (公益財団法人 新日本先進医療研究財団)

Takeda Science Foundation (TSF)

Japan Medical Association (JMA)

MEXT | Japan Society for the Promotion of Science (JSPS)

Ohara Pharmaceuticals (Ohara)

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ARTICLE ABSTRACT

The standard treatment for elderly patients with AML is Ven combined with HMAs. OR21, a new oral HMA plus Ven showed synergistic antileukemia effects in vitro and vivo, suggesting that the combination of OR2100 plus Ven is a promising candidate oral therapy for AML.

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    Cancer Research Communications

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    Keywords

    Hematological CancersLeukemiasDrug TargetsCell SignalingCell Death And Senescencebcl-2 pathways

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