Figure S4 from Proteasome Inhibitors Silence Oncogenes in Multiple Myeloma through Localized Histone Deacetylase 3 Stabilization and Chromatin Condensation

Maneix, Laure; Iakova, Polina; Moree, Shannon E.; Hsu, Joanne I.; Mistry, Ragini M.; Stossi, Fabio; Lulla, Premal; Sun, Zheng; Sahin, Ergun; Yellapragada, Sarvari V.; Catic, André

doi:10.1158/2767-9764.22546589.v1

crc-22-0255-s05.pdf (444.5 kB)

Figure S4 from Proteasome Inhibitors Silence Oncogenes in Multiple Myeloma through Localized Histone Deacetylase 3 Stabilization and Chromatin Condensation

journal contribution

posted on 2023-04-04, 02:05 authored by Laure Maneix, Polina Iakova, Shannon E. Moree, Joanne I. Hsu, Ragini M. Mistry, Fabio Stossi, Premal Lulla, Zheng Sun, Ergun Sahin, Sarvari V. Yellapragada, André Catic

DNA site-specific stabilization of HDAC3 by proteasome inhibition in MM cells.

Funding

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

HHS | NIH | National Institute of General Medical Sciences (NIGMS)

Cancer Prevention and Research Institute of Texas (CPRIT)

HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI)

HHS | NIH | National Institute on Aging (NIA)

HHS | NIH | National Cancer Institute (NCI)

HHS | NIH | Office of Research Infrastructure Programs, National Institutes of Health (ORIP)

HHS | NIH | National Center for Research Resources (NCRR)

HHS | NIH | National Institute of Environmental Health Sciences (NIEHS)

History

ARTICLE ABSTRACT

Integrative genomics reveals that a key function of proteasome inhibitors involves limiting the activity of MYC and MYC-dependent genes through epigenetic repression.