Figure S4 from Loss of Dok-3 in Non-tumor Cells Induces Malignant Transformation of Benign Epithelial Tumor Cells of the Intestine

Arimura, Sumimasa; Inoue-Yamauchi, Akane; Katayama, Kotoe; Kanno, Tatsuo; Jozawa, Hiroki; Imoto, Seiya; Yamanashi, Yuji

doi:10.1158/2767-9764.22546200.v1

Figure S4 from Loss of Dok-3 in Non-tumor Cells Induces Malignant Transformation of Benign Epithelial Tumor Cells of the Intestine

https://doi.org/10.1158/2767-9764.22546200

journal contribution

posted on 2023-04-04, 02:02 authored by Sumimasa Arimura, Akane Inoue-Yamauchi, Kotoe Katayama, Tatsuo Kanno, Hiroki Jozawa, Seiya Imoto, Yuji Yamanashi

<p>Stromal reaction associated with invasive tumors of Apc/Dok3 mice.</p>

Funding

MEXT | Japan Society for the Promotion of Science (JSPS)

OU | Research Institute for Microbial Diseases, Osaka University (RIMD)

History

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DOI - Is supplement to Loss of Dok-3 in Non-tumor Cells Induces Malignant Transformation of Benign Epithelial Tumor Cells of the Intestine

ARTICLE ABSTRACT

This study uncovers tumor cell–extrinsic cues that can induce malignant conversion of benign tumors without intensifying mutagenesis in tumors, a novel concept potentially providing a new therapeutic target in malignancy.