Figure S4 from Characterizing the Immune Microenvironment and Neoantigen Landscape of Hürthle Cell Carcinoma to Identify Potential Immunologic Vulnerabilities

Ganly, Ian; Kuo, Fengshen; Makarov, Vladimir; Dong, Yiyu; Ghossein, Ronald; Xu, Bin; Morris, Luc G.T.; Chan, Timothy A.

doi:10.1158/2767-9764.23808311.v1

Figure S4 from Characterizing the Immune Microenvironment and Neoantigen Landscape of Hürthle Cell Carcinoma to Identify Potential Immunologic Vulnerabilities

journal contribution

posted on 2023-07-31, 14:20 authored by Ian Ganly, Fengshen Kuo, Vladimir Makarov, Yiyu Dong, Ronald Ghossein, Bin Xu, Luc G.T. Morris, Timothy A. Chan

RNA-seq Immune infiltration stratified by LOH.

Funding

HHS | NIH | NCI | National Cancer Institute (NCI)

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ARTICLE ABSTRACT

The immune landscape of HCC is poorly defined and response rates to immunotherapy have not been reported. The authors found the immune microenvironment in HCC to be depleted. This immunosuppression is associated with a global LOH from haploidization and uniparental disomy, resulting in whole chromosome losses across the genome.

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Immunotherapy Head, Neck & Oral Cancers Tumor Microenvironment Immune cells and the microenvironment Gene Technologies High-throughput sequencing Genome Biology Comparative transcriptomics Structural genomics Immunology Immune responses to cancer

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CC BY

Figure S4 from Characterizing the Immune Microenvironment and Neoantigen Landscape of Hürthle Cell Carcinoma to Identify Potential Immunologic Vulnerabilities

Funding

HHS | NIH | NCI | National Cancer Institute (NCI)

History

ARTICLE ABSTRACT

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