American Association for Cancer Research
crc-23-0120-s04.pdf (244.7 kB)

Figure S4 from Characterizing the Immune Microenvironment and Neoantigen Landscape of Hürthle Cell Carcinoma to Identify Potential Immunologic Vulnerabilities

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journal contribution
posted on 2023-07-31, 14:20 authored by Ian Ganly, Fengshen Kuo, Vladimir Makarov, Yiyu Dong, Ronald Ghossein, Bin Xu, Luc G.T. Morris, Timothy A. Chan

RNA-seq Immune infiltration stratified by LOH.


HHS | NIH | NCI | National Cancer Institute (NCI)



The immune landscape of HCC is poorly defined and response rates to immunotherapy have not been reported. The authors found the immune microenvironment in HCC to be depleted. This immunosuppression is associated with a global LOH from haploidization and uniparental disomy, resulting in whole chromosome losses across the genome.