American Association for Cancer Research
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Figure S4 from Cell-free DNA Predicts Prolonged Response to Multi-agent Chemotherapy in Pancreatic Ductal Adenocarcinoma

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journal contribution
posted on 2023-04-04, 01:42 authored by Eric S. Christenson, Su Jin Lim, Jennifer Durham, Ana De Jesus-Acosta, Katherine Bever, Daniel Laheru, Amy Ryan, Parul Agarwal, Robert B. Scharpf, Dung T. Le, Hao Wang

Supplemental Figure 4. Spaghetti plot of tumor mutation VAF changes with 2 cycles of GAX-CI. To determine the impact of GAX-CI on the allelic frequency of mutations detected in ctDNA, we measured the VAF of these mutations pre-treatment and after 2 cycles of GAX-CI. The mutations detected for a given patient were plotted using a spaghetti plot to provide a visual representation of the change in VAF with treatment.


HHS | National Institutes of Health (NIH)

Swim Across America (SAA)

Cynthia Boscov Fund for Pancreatic Cancer Research

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The Charles and Margaret Levin Family Foundation

The McCance Foundation

The Wyman Family Foundation

Cancer Convergence Institute



We report on the association of cfDNA with response durability for patients undergoing treatment with a novel metronomic chemotherapy regimen (gemcitabine, nab-paclitaxel, capecitabine, cisplatin, irinotecan; GAX-CI) for metastatic PDAC. This investigation offers encouraging evidence that cfDNA may prove to be a valuable diagnostic tool to guide clinical management.