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Figure S3 from Proteasome Inhibitors Silence Oncogenes in Multiple Myeloma through Localized Histone Deacetylase 3 Stabilization and Chromatin Condensation

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posted on 2023-04-04, 02:06 authored by Laure Maneix, Polina Iakova, Shannon E. Moree, Joanne I. Hsu, Ragini M. Mistry, Fabio Stossi, Premal Lulla, Zheng Sun, Ergun Sahin, Sarvari V. Yellapragada, André Catic

Proteasome inhibition represses cell proliferation and mitochondrial activity in MM.

Funding

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

HHS | NIH | National Institute of General Medical Sciences (NIGMS)

Cancer Prevention and Research Institute of Texas (CPRIT)

HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI)

HHS | NIH | National Institute on Aging (NIA)

HHS | NIH | National Cancer Institute (NCI)

HHS | NIH | Office of Research Infrastructure Programs, National Institutes of Health (ORIP)

HHS | NIH | National Center for Research Resources (NCRR)

HHS | NIH | National Institute of Environmental Health Sciences (NIEHS)

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ARTICLE ABSTRACT

Integrative genomics reveals that a key function of proteasome inhibitors involves limiting the activity of MYC and MYC-dependent genes through epigenetic repression.

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    Cancer Research Communications

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    Keywords

    Hematological CancersMyelomasEpigeneticsChromatin structure and functionGene silencingDrug MechanismsCellular responses to anticancer drugsOncogenes & Tumor SuppressorsOncogenesSmall Molecule AgentsProteasome inhibitors

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