Figure S2 from Structures of Cancer Antigen Mesothelin and Its Complexes with Therapeutic Antibodies

Zhan, Jingyu; Lin, Dong; Watson, Nathan; Esser, Lothar; Tang, Wai Kwan; Zhang, Alex; Liu, Xiufen; Hassan, Raffit; Gleinich, Anne; Shajahan, Asif; Azadi, Parastoo; Pastan, Ira; Xia, Di

doi:10.1158/2767-9764.22546337.v1

crc-22-0306-s03.pdf (1.18 MB)

Figure S2 from Structures of Cancer Antigen Mesothelin and Its Complexes with Therapeutic Antibodies

journal contribution

posted on 2023-04-04, 02:03 authored by Jingyu Zhan, Dong Lin, Nathan Watson, Lothar Esser, Wai Kwan Tang, Alex Zhang, Xiufen Liu, Raffit Hassan, Anne Gleinich, Asif Shajahan, Parastoo Azadi, Ira Pastan, Di Xia

Comparison of experimental MSLN structure with those of computational models.

Funding

HHS | National Institutes of Health (NIH)

History

ARTICLE ABSTRACT

The structures of full-length mesothelin and its complexes with antibodies reported here are the first to be determined experimentally, providing atomic models for structural organization of this protein and its interactions with antibodies. It offers insights into the function of mesothelin and guidance for further development of therapeutic antibodies.