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Figure S2 from Single-cell Profiling Uncovers a Muc4-Expressing Metaplastic Gastric Cell Type Sustained by Helicobacter pylori-driven Inflammation

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posted on 2023-09-06, 17:07 authored by Valerie P. O'Brien, Yuqi Kang, Meera K. Shenoy, Greg Finak, William C. Young, Julien Dubrulle, Lisa Koch, Armando E. Rodriguez Martinez, Jeffery Williams, Elizabeth Donato, Surinder K. Batra, Cecilia C.S. Yeung, William M. Grady, Meghan A. Koch, Raphael Gottardo, Nina R. Salama

Cell cluster frequencies change according to Hp infection status and induction of constitutively active KRAS.

Funding

Gastric Cancer Foundation (GCF)

HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID)

HHS | NIH | National Cancer Institute (NCI)

Cancer Research Institute (CRI)

American Association for Cancer Research (AACR)

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ARTICLE ABSTRACT

Using a mouse model, we have delineated metaplastic pit cells as a precancerous cell type whose expansion requires Hp-driven inflammation. In humans, metaplastic pit cells show enhanced proliferation as well as enrichment in precancer and early cancer tissues, highlighting an early step in the gastric metaplasia to cancer cascade.

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    Cancer Research Communications

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    Keywords

    Gastrointestinal CancersStomach cancerImmunologyTumor immunology animal modelsCarcinogenesisPremalignancyTumor initiation and promotionPreclinical ModelsAnimal models of cancerTumor MicroenvironmentMicrobiome and the microenvironmentInflamation and the microenvironment

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