American Association for Cancer Research
Browse

Figure S2 from Proteasome Inhibitors Silence Oncogenes in Multiple Myeloma through Localized Histone Deacetylase 3 Stabilization and Chromatin Condensation

Download (384.34 kB)
journal contribution
posted on 2023-04-04, 02:20 authored by Laure Maneix, Polina Iakova, Shannon E. Moree, Joanne I. Hsu, Ragini M. Mistry, Fabio Stossi, Premal Lulla, Zheng Sun, Ergun Sahin, Sarvari V. Yellapragada, André Catic

Proteasome inhibition down-regulates cell cycle and mitochondrial gene expression in three different MM cell lines.

Funding

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

HHS | NIH | National Institute of General Medical Sciences (NIGMS)

Cancer Prevention and Research Institute of Texas (CPRIT)

HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI)

HHS | NIH | National Institute on Aging (NIA)

HHS | NIH | National Cancer Institute (NCI)

HHS | NIH | Office of Research Infrastructure Programs, National Institutes of Health (ORIP)

HHS | NIH | National Center for Research Resources (NCRR)

HHS | NIH | National Institute of Environmental Health Sciences (NIEHS)

History

ARTICLE ABSTRACT

Integrative genomics reveals that a key function of proteasome inhibitors involves limiting the activity of MYC and MYC-dependent genes through epigenetic repression.