American Association for Cancer Research
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Figure S2 from Polyunsaturated Fatty Acids from Astrocytes Activate PPARγ Signaling in Cancer Cells to Promote Brain Metastasis

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posted on 2023-04-03, 22:41 authored by Yongkang Zou, Andrea Watters, Nan Cheng, Caroline E. Perry, Ke Xu, Gretchen M. Alicea, Joshua L.D. Parris, Ezra Baraban, Pulak Ray, Anupma Nayak, Xiaowei Xu, Meenhard Herlyn, Maureen E. Murphy, Ashani T. Weeraratna, Zachary T. Schug, Qing Chen

Figure S2 shows astrocytes facilitate the growth and survival of brain metastatic cancer cells.

Funding

Jayne Koskinas Ted Giovanis Foundation for Health and Policy

V Foundation for Cancer Research

The Ching Jer Chern Memorial Award

History

ARTICLE ABSTRACT

Brain metastasis, the most lethal form of melanoma and carcinoma, is the consequence of favorable interactions between the invading cancer cells and the brain cells. Peroxisome proliferator–activated receptor γ (PPARγ) has ambiguous functions in cancer development, and its relevance in advanced brain metastasis remains unclear. Here, we demonstrate that astrocytes, the unique brain glial cells, activate PPARγ in brain metastatic cancer cells. PPARγ activation enhances cell proliferation and metastatic outgrowth in the brain. Mechanistically, astrocytes have a high content of polyunsaturated fatty acids that act as “donors” of PPARγ activators to the invading cancer cells. In clinical samples, PPARγ signaling is significantly higher in brain metastatic lesions. Notably, systemic administration of PPARγ antagonists significantly reduces brain metastatic burden in vivo. Our study clarifies a prometastatic role for PPARγ signaling in cancer metastasis in the lipid-rich brain microenvironment and argues for the use of PPARγ blockade to treat brain metastasis. Brain-tropic cancer cells take advantage of the lipid-rich brain microenvironment to facilitate their proliferation by activating PPARγ signaling. This protumor effect of PPARγ in advanced brain metastases is in contrast to its antitumor function in carcinogenesis and early metastatic steps, indicating that PPARγ has diverse functions at different stages of cancer development.This article is highlighted in the In This Issue feature, p. 1631

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