Quantification of mitochondrial DNA (mtDNA) following transfer of MSC mitochondria to GSCs (A) Detection of MSC mtDNA in GSCs. MSC mtDNA concentrations are expressed relative to GSC mtDNA. Mean with SEM, t test with Welch correction, *p < 0.05. (B) Total mtDNA concentrations in GSCs at different time points after MSC mitochondria transfer, expressed relative to GSC genomic DNA. Mean + SEM and multiple t tests, *p < 0.05.
Funding
Ligue Contre le Cancer (French League Against Cancer)
Fondation ARC pour la Recherche sur le Cancer (ARC)
Institut National Du Cancer (INCa)
Région Occitanie Pyrénées-Méditerranée
History
ARTICLE ABSTRACT
Mitochondria acquired from MSCs enhance the chemoresistance of GBMs. The discovery that they also generate metabolic vulnerability in GSCs paves the way for novel therapeutic approaches.