American Association for Cancer Research
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Figure S1 from Tumor-derived GCSF Alters Tumor and Systemic Immune System Cell Subset Composition and Signaling

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posted on 2023-04-04, 02:21 authored by Israel Matos, Maunish Barvalia, Manreet K. Chehal, A. Gordon Robertson, Iva Kulic, Jessica A.F.D. Silva, Abhinandan Ranganathan, Amy Short, Yu-Hsuan Huang, Erin Long, John J. Priatel, Salim Dhanji, Brad H. Nelson, Danielle L. Krebs, Kenneth W. Harder

Supplementary Figure S1 shows the characterization of MT and MTG-CSF-/- cell lines and tumors, including surface protein expression, tumor volume/weight, and immune cell subset content. Composition of immune cells in blood and spleen of MT and MTG-CSF-/- mice is also shown.

Funding

Gouvernement du Canada | Canadian Institutes of Health Research (IRSC)

Michael Smith Health Research BC (MSFHR)

Canadian Breast Cancer Foundation

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ARTICLE ABSTRACT

Tumor-derived GCSF leads to systemic immune population changes. GCSF blockade restores immune populations, improves immunotherapy, and reduces tumor size, paralleling human colorectal cancer data. GCSF inhibition may synergize with current immunotherapies to treat GCSF-secreting tumors.

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    Cancer Research Communications

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    Keywords

    Breast CancerGastrointestinal CancersColorectal cancerTumor MicroenvironmentCytokines and the microenvironmentImmune cells and the microenvironmentSystems BiologyImmunotherapySingle Cell TechnologiesImmunologyTumor immunology animal models

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