American Association for Cancer Research
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Figure S1 from Prenatal Exposure to Chemotherapy Increases the Mutation Burden in Human Neonatal Hematopoietic Stem Cells

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posted on 2025-05-02, 07:20 authored by Ilana Struys, Carolina Velázquez, Joske Ubels, Charlotte L. LeJeune, Markus J. van Roosmalen, Axel K.M. Rosendahl Huber, Anais J.C.N. van Leeuwen, Wouter Bossuyt, Bernard Thienpont, Thierry Voet, Kristel Van Calsteren, Liesbeth Lenaerts, Ruben van Boxtel, Frédéric Amant

FigureS1 showing the assessment of possible maternal contamination in the cord blood samples.

Funding

Stichting Tegen Kanker (Fondation Contre le Cancer)

KU Leuven (Katholieke Universiteit Leuven)

Kom op tegen Kanker (Fight Cancer)

Fonds Wetenschappelijk Onderzoek (FWO)

European Commission (EC)

HORIZON EUROPE European Research Council (ERC)

New York Stem Cell Foundation (NYSCF)

Rijksdienst voor Ondernemend Nederland (RVO)

History

ARTICLE ABSTRACT

This study demonstrates that environmental mutagenic exposure during pregnancy can increase somatic mutation accumulation in the fetus. Given that detrimental early life exposures can adversely affect health outcomes later in life, our study highlights the need for further research into the impact of environmentally induced genomic insults during the perinatal period.See related commentary by Furudate and Takahashi, p. 870

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    Cancer Discovery

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    Keywords

    ChemotherapyEnvironmental Risk FactorsSingle Cell Technologies

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    CC BY

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