American Association for Cancer Research
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Figure S1 from Effectiveness and Cost of an Enhanced Mailed Fecal Test Outreach Colorectal Cancer Screening Program: Findings from the PROMPT Stepped-Wedge Trial

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posted on 2023-11-01, 07:40 authored by Gloria D. Coronado, Denis B. Nyongesa, Anne L. Escaron, Amanda F. Petrik, Jamie H. Thompson, Dave Smith, Melinda M. Davis, Jennifer L. Schneider, Jennifer S. Rivelli, Tanya Laguna, Michael C. Leo

Supplementary Figure S1 shows the proportion completing FIT within 6-months of patient identification for each evaluation interval (baseline, year 1, and year 2), by study condition.


National Institutes of Health (NIH)



Mailed fecal immunochemical test (FIT) outreach can improve colorectal cancer screening rates, yet little is known about how to optimize these programs for effectiveness and cost. PROMPT was a pragmatic, stepped-wedge, cluster-randomized effectiveness trial of mailed FIT outreach. Participants in the standard condition were mailed a FIT and received live telephone reminders to return it. Participants in the enhanced condition also received a tailored advance notification (text message or live phone call) and two automated phone call reminders. The primary outcome was 6-month FIT completion; secondary outcomes were any colorectal cancer screening completion at 6 months, implementation, and program costs. The study included 27,585 participants (80% ages 50–64, 82% Hispanic/Latino; 68% preferred Spanish). A higher proportion of enhanced participants completed FIT at 6 months than standard participants, both in intention-to-treat [+2.8%, 95% confidence interval (CI; 0.4–5.2)] and per-protocol [limited to individuals who were reached; +16.9%, 95% CI (12.3–20.3)] analyses. Text messages and automated calls were successfully delivered to 91% to 100% of participants. The per-patient cost for standard mailed FIT was $10.84. The enhanced program's text message plus automated call reminder cost an additional $0.66; live phone calls plus an automated call reminder cost an additional $10.82 per patient. Adding advance notifications and automated calls to a standard mailed FIT program boosted 6-month FIT completion rates at a small additional per-patient cost. Enhancements to mailed FIT outreach can improve colorectal cancer screening participation. Future research might test the addition of educational video messaging for screening-naïve adults.

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