Figure S14 from Single-cell Profiling Uncovers a Muc4-Expressing Metaplastic Gastric Cell Type Sustained by Helicobacter pylori-driven Inflammation

O'Brien, Valerie P.; Kang, Yuqi; Shenoy, Meera K.; Finak, Greg; Young, William C.; Dubrulle, Julien; Koch, Lisa; Rodriguez Martinez, Armando E.; Williams, Jeffery; Donato, Elizabeth; Batra, Surinder K.; Yeung, Cecilia C.S.; Grady, William M.; Koch, Meghan A.; Gottardo, Raphael; Salama, Nina R.

doi:10.1158/2767-9764.24089938.v1

Figure S14 from Single-cell Profiling Uncovers a Muc4-Expressing Metaplastic Gastric Cell Type Sustained by Helicobacter pylori-driven Inflammation

journal contribution

posted on 2023-09-06, 17:07 authored by Valerie P. O'Brien, Yuqi Kang, Meera K. Shenoy, Greg Finak, William C. Young, Julien Dubrulle, Lisa Koch, Armando E. Rodriguez Martinez, Jeffery Williams, Elizabeth Donato, Surinder K. Batra, Cecilia C.S. Yeung, William M. Grady, Meghan A. Koch, Raphael Gottardo, Nina R. Salama

Figure S14. Metaplastic pit cells can be seen in gastric cancer samples.

Funding

Gastric Cancer Foundation (GCF)

HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID)

HHS | NIH | National Cancer Institute (NCI)

Cancer Research Institute (CRI)

American Association for Cancer Research (AACR)

History

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DOI - Is supplement to Single-cell Profiling Uncovers a Muc4-Expressing Metaplastic Gastric Cell Type Sustained by Helicobacter pylori-driven Inflammation

ARTICLE ABSTRACT

Using a mouse model, we have delineated metaplastic pit cells as a precancerous cell type whose expansion requires Hp-driven inflammation. In humans, metaplastic pit cells show enhanced proliferation as well as enrichment in precancer and early cancer tissues, highlighting an early step in the gastric metaplasia to cancer cascade.