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Figure FS6 from Loss of the Volume-regulated Anion Channel Components LRRC8A and LRRC8D Limits Platinum Drug Efficacy

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posted on 2023-04-04, 01:43 authored by Carmen A. Widmer, Ismar Klebic, Natalya Domanitskaya, Morgane Decollogny, Denise Howald, Myriam Siffert, Paul Essers, Zuzanna Nowicka, Nadine Stokar-Regenscheit, Marieke van de Ven, Renske de Korte-Grimmerink, José A. Galván, Colin E.J. Pritchard, Ivo J. Huijbers, Wojciech Fendler, Conchita Vens, Sven Rottenberg

Analysis of publicly available ovarian cancer dataset to identify the association of LRRC8A or LRRC8D expression with outcome of chemotherapy with cisplatin

Funding

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (SNF)

EC | ERC | HORIZON EUROPE European Research Council (ERC)

Krebsliga Schweiz (Swiss Cancer League)

Wilhelm Sander-Stiftung (Wilhelm Sander Foundation)

History

ARTICLE ABSTRACT

We demonstrate that lack of expression of Lrrc8a or Lrrc8d significantly reduces the uptake and efficacy of cisplatin and carboplatin in Pt-sensitive BRCA1;p53-deficient tumors. Moreover, our work provides support to confirm the LRRC8A and LRRC8D gene expression in individual tumors prior to initiation of intensive Pt-based chemotherapy.

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    Cancer Research Communications

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    Keywords

    BiomarkersBreast CancerDrug ResistanceHead, Neck & Oral CancersChemotherapyPrecision Medicine

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    CC BY

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