Percentage of PD-1+ CD8 T+ and PD-L1+ CD8 T+ cells in respective immune subtypes. (a, b) Data were presented as a percentage of PD-1+ cells (a) and PD-L1+ cells (b) per indicated CD8+ T cell subset in LUAD and LUSQ. % naïve CD8; percentage of PD-1+ or PD-L1+ naïve CD8+ T cell subset per total of naïve CD8+ T cells. % CM CD8; percentage of PD-1+ or PD-L1+ CM CD8+ T cell subset per total of CM CD8+ T cells. % EM CD8; percentage of PD-1+ or PD-L1+ EM CD8+ T cell subset per total of EM CD8+ T cells. % EMRA CD8; percentage of PD-1+ or PD-L1+ EMRA CD8+ T cell subset per total of EMRA CD8+ T cells. ns; not significant. * p<0.05. **P<0.01.
Funding
Japan Agency for Medical Research and Development (AMED)
National Cancer Center Japan (NCC)
MEXT | Japan Society for the Promotion of Science (JSPS)
History
ARTICLE ABSTRACT
The precise TIL profiling classified NSCLC into novel three immune subtypes that correlates with patient outcome, identifying subtype-specific molecular pathways and genomic alterations that should play important roles in constructing subtype-specific immune tumor microenvironments. These classifications of NSCLC based on TIL status are useful for developing personalized immune therapies for NSCLC.