Supplementary data from Inhibition of SOAT1 Suppresses Glioblastoma Growth via Blocking SREBP-1–Mediated Lipogenesis

<p>Supplementary Figure 1. TIP47 staining represents lipid droplets in cancer cell lines. Supplementary Figure 2. LD number is correlated with Ki67 positive percentage in GBM patient tumor tissues. Supplementary Figure 3. SOAT1 is majorly expressed in GBM patient tumor tissues and cell lines. Supplementary Figure 4. Genetic or pharmacologic inhibition of SOAT1 suppresses lipid droplet formation in GBM cells. Supplementary Figure 5. Genetic or pharmacologic inhibition of SOAT1 does not significantly advance GBM cell cholesterol levels. Supplementary Figure 6. Genetic or pharmacologic inhibition of SOAT1 suppresses SREBP-1 activation and reduces the expression of its downstream targets. Supplementary Figure 7. Inhibition of SOAT1 has no inhibitory effect on LDL uptake.</p>