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Supplementary Table S2 from Chromatin-Associated Protein SIN3B Prevents Prostate Cancer Progression by Inducing Senescence

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posted on 2023-03-31, 00:44 authored by Anthony J. Bainor, Fang-Ming Deng, Yu Wang, Peng Lee, David J. Cantor, Susan K. Logan, Gregory David

Patient data for the eight SIN3B target genes which are unregulated in human PCa compared to normal tissue and exhibit a significant decrease in disease-free survival following radical prostatectomy.

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NIH

NCI

Samuel Waxman Cancer Research Foundation

NYU

NRSA

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ARTICLE ABSTRACT

Distinguishing between indolent and aggressive prostate adenocarcinoma remains a priority to accurately identify patients who need therapeutic intervention. SIN3B has been implicated in the initiation of senescence in vitro. Here we show that in a mouse model of prostate cancer, SIN3B provides a barrier to malignant progression. SIN3B was required for PTEN-induced cellular senescence and prevented progression to invasive prostate adenocarcinoma. Furthermore, SIN3B was downregulated in human prostate adenocarcinoma correlating with upregulation of its target genes. Our results suggest a tumor suppressor function for SIN3B that limits prostate adenocarcinoma progression, with potential implications for the use of SIN3B and its target genes as candidate diagnostic markers to distinguish indolent from aggressive disease. Cancer Res; 77(19); 5339–48. ©2017 AACR.

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Keywords

Cell Death And Senescence Cellular aging and senescence Genitourinary Cancers Prostate cancer Preclinical Models Animal models of cancer Progression, Invasion & Metastasis

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