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Supplementary Figures from Extrachromosomal Amplification of Human Papillomavirus Episomes Is a Mechanism of Cervical Carcinogenesis

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posted on 2023-06-02, 08:21 authored by Nicole M. Rossi, Jieqiong Dai, Yi Xie, Darawalee Wangsa, Kerstin Heselmeyer-Haddad, Hong Lou, Joseph F. Boland, Meredith Yeager, Roberto Orozco, Enrique Alvirez Freites, Lisa Mirabello, Eduardo Gharzouzi, Michael Dean

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National Cancer Institute (NCI)

United States Department of Health and Human Services

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ARTICLE ABSTRACT

Multimers of the HPV genome are generated in cervical tumors replicating as extrachromosomal episomes, which is associated with deletion and rearrangement of the HPV genome and provides a mechanism for oncogenesis without integration.

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