can-22-3030_supplementary_figures_suppsf1-sf9.pptx (1.57 MB)

Supplementary Figures from Extrachromosomal Amplification of Human Papillomavirus Episomes Is a Mechanism of Cervical Carcinogenesis

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posted on 2023-06-02, 08:21 authored by Nicole M. Rossi, Jieqiong Dai, Yi Xie, Darawalee Wangsa, Kerstin Heselmeyer-Haddad, Hong Lou, Joseph F. Boland, Meredith Yeager, Roberto Orozco, Enrique Alvirez Freites, Lisa Mirabello, Eduardo Gharzouzi, Michael Dean

Supplementary figures

Funding

National Cancer Institute (NCI)

United States Department of Health and Human Services

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ARTICLE ABSTRACT

Multimers of the HPV genome are generated in cervical tumors replicating as extrachromosomal episomes, which is associated with deletion and rearrangement of the HPV genome and provides a mechanism for oncogenesis without integration.